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Study Results


24 February 2015

The PROUD study today reported that PrEP reduced the risk of HIV infection by 86% for gay and other men who have sex with men when delivered in sexual health clinics in England.

The PROUD study measured the effectiveness of daily PrEP for gay and other men who have sex with men in England.  The results released at the Conference on Retroviruses and Opportunistic Infections today indicate that PrEP is highly protective for this group, reducing the risk of infection by 86%. The researchers concluded that PrEP offers a major opportunity to curb new HIV infections in men who have sex with men in the UK.

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The PROUD Study


Examining the impact on gay men of using Pre-Exposure Prophylaxis (PrEP)


What is PrEP?


PrEP (Pre-Exposure Prophylaxis) is a new way to reduce the risk of getting HIV. It involves HIV negative people taking a daily tablet that contains drugs commonly used to treat HIV.

PROUD is a two-year study to recruit volunteers across England, who will be placed at random into one of two groups. One group will use PrEP from the start of the study, and the other group will receive PrEP after 12 months.

Truvada (which contains tenofovir and emtricitabine, also called FTC) is used in this study. Truvada is already widely used and any side effects are usually mild.

Previous studies with gay men found that using PrEP almost halved HIV infections – and there were even fewer infections amongst men who took their pill every day.

Other News

The world premiere screening of the PROUD documentary https://vimeo.com/132412294 took place in London on 1st July 2015.

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If you would like to receive updates on the development of a research agenda around PrEP including future PrEP studies, and on the development of a PrEP policy in the UK, you can sign up to the new MRC CTU PrEP Update mailing list at www.proud.mrc.ac.uk/PrEPupdate.

19 January 2014

WITHDRAWN PLANS TO EXPAND PROUD STUDY

Given that the PROUD pilot study has answered the important question of how much protection daily Truvada can offer when provided in sexual health clinics in the UK, there is no need for the planned larger clinical trial. As such, we have withdrawn our funding application to reopen the PROUD study for new recruitment.

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Trial participants can now use a mobile format to complete their diary and questionnaires.            This can be found at https://ctuapps.ctu.mrc.ac.uk/
ProudMobile

HIV charities release joint statement on PrEP

A group of the UK’s leading HIV charities have released a joint statement outlining their position on Pre-Exposure Prophylaxis (PrEP). Read more

Recruitment

Recruitment has been running since November 2012 and 544 men have been recruited from the UK clinics listed below. Recruitment to the pilot is now complete.

544

The PROUD study has recruited in:

  • London (8 sites)
  • Brighton
  • Birmingham
  • York
  • Manchester
  • Sheffield

For participating clinic address/contact information, please [click here].