Latest News

Study Results

24 February 2015

The PROUD study today reported that PrEP reduced the risk of HIV infection by 86% for gay and other men who have sex with men when delivered in sexual health clinics in England.

The PROUD study measured the effectiveness of daily PrEP for gay and other men who have sex with men in England.  The results released at the Conference on Retroviruses and Opportunistic Infections today indicate that PrEP is highly protective for this group, reducing the risk of infection by 86%. The researchers concluded that PrEP offers a major opportunity to curb new HIV infections in men who have sex with men in the UK.

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The PROUD Study

Examining the impact on gay men of using Pre-Exposure Prophylaxis (PrEP)

What is PrEP?

PrEP (Pre-Exposure Prophylaxis) is a new way to reduce the risk of getting HIV. It involves HIV negative people taking a daily tablet that contains drugs commonly used to treat HIV.

PROUD is a two-year study to recruit volunteers across England, who will be placed at random into one of two groups. One group will use PrEP from the start of the study, and the other group will receive PrEP after 12 months.

Truvada (which contains tenofovir and emtricitabine, also called FTC) is used in this study. Truvada is already widely used and any side effects are usually mild.

Previous studies with gay men found that using PrEP almost halved HIV infections – and there were even fewer infections amongst men who took their pill every day.

Volunteer to take part in the study

  • Are you a gay or bisexual man?
  • Have you recently had sex without a condom?
  • Are you willing to take part in research that aims to reduce your risk of HIV?

Participation is straightforward and won’t take much of your time. Click here to find out more about Volunteering.

Other News

19 January 2014


Given that the PROUD pilot study has answered the important question of how much protection daily Truvada can offer when provided in sexual health clinics in the UK, there is no need for the planned larger clinical trial. As such, we have withdrawn our funding application to reopen the PROUD study for new recruitment.

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Trial participants can now use a mobile format to complete their diary and questionnaires.            This can be found at

HIV charities release joint statement on PrEP

A group of the UK’s leading HIV charities have released a joint statement outlining their position on Pre-Exposure Prophylaxis (PrEP). Read more


Recruitment has been running since November 2012 and 545 men have been recruited from the UK clinics listed below. Recruitment to the pilot is now complete.


The PROUD study has recruited in:

  • London (8 sites)
  • Brighton
  • Birmingham
  • York
  • Manchester
  • Sheffield

For participating clinic address/contact information, please [click here].