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The PROUD Study


Examining the impact on gay men of using Pre-Exposure Prophylaxis (PrEP)


What is PrEP?


PrEP (Pre-Exposure Prophylaxis) is a new way to reduce the risk of getting HIV. It involves HIV negative people taking a daily tablet that contains drugs commonly used to treat HIV.

PROUD is a two-year study to recruit volunteers across England, who will be placed at random into one of two groups. One group will use PrEP from the start of the study, and the other group will receive PrEP after 12 months.

Truvada (which contains tenofovir and emtricitabine, also called FTC) is used in this study. Truvada is already widely used and any side effects are usually mild.

Previous studies with gay men found that using PrEP almost halved HIV infections – and there were even fewer infections amongst men who took their pill every day.

Volunteer to take part in the study


  • Are you a gay or bisexual man?
  • Have you recently had sex without a condom?
  • Are you willing to take part in research that aims to reduce your risk of HIV?

Participation is straightforward and won’t take much of your time. Click here to find out more about Volunteering.

News

 

PROUD Pilot Study Update

 

PROUD pilot study

The PROUD Trial Steering Committee (TSC) supported the Trial Management Group’s (TMG) request to submit an application for funding for a full PROUD trial of PrEP among gay men and other men who have sex with men in the UK. An application was submitted to the UK National Institute of Health Research (NIHR), Health Technology Assessment (HTA) researcher led call on 6th January 2014.

Read more

Latest News

20 November 2014

UPDATE ON TRIAL TIMELIMES

In April 2014, we announced that we had applied for additional funding to expand the PROUD pilot study into a full trial and if successful, hoped to reopen for recruitment early in 2015. A number of volunteers have already added their names to clinic registers of people interested in PrEP so they can be informed if recruitment reopens.

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16 October 2014

An interim analysis of the PROUD study data has shown that pre-exposure prophylaxis (PrEP) is highly protective against HIV for gay men and other men who have sex with men (MSM) at high risk of infection.

Read more

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Trial participants can now use a mobile format to complete their diary and questionnaires.            This can be found at https://ctuapps.ctu.mrc.ac.uk/
ProudMobile

HIV charities release joint statement on PrEP

A group of the UK’s leading HIV charities have released a joint statement outlining their position on Pre-Exposure Prophylaxis (PrEP). [read more]

Recruitment

Recruitment has been running since November 2012 and 545 men have been recruited from the UK clinics listed below. Recruitment to the pilot is now complete.

545

The PROUD study has recruited in:

  • London (8 sites)
  • Brighton
  • Birmingham
  • York
  • Manchester
  • Sheffield

For participating clinic address/contact information, please [click here].